Sickle Cell Trait and Sickle Cell Disease Associated with Increased Risk of Stillbirth

Pregnant women with sickle cell trait (SCT) have an increased risk of stillbirth, according to a study published online November 24, 2021 in JAMA network.

Silvia P. Canelón (PhD) and her colleagues at the University of Pennsylvania, Philadelphia, conducted a retrospective study of 50,560 women and 63334 deliveries from 2010 to 2017 to determine if there was an association between SCT and stillbirth.

The study found that among the 63,334 deliveries, the prevalence of stillbirth was slightly higher in patients with SCT (1.1) than in the general population (0.8%). After adjustment for all risk factors, patients with SCT were found to have a statistically significantly higher risk than those without SCT (P = 0.045). Patients with Sickle cell disease (SCD) had an even higher risk of stillbirth. The prevalence of stillbirth in this population is 2.3%, which is higher than those with SCT (1.1%) and the general population (0.8%). In addition, they found that blacks had a higher risk of stillbirth than blacks without SCD (p=0.007).

“These findings demonstrate that pregnant patients with SCT experience severe health complications, underscoring the importance of additional risk assessment for SCT.” authors write.

Source : JAMA network.