Mobil-O-Graph Monitor Identifies Several Parameters Linked with PAD

Total vascular resistance (TVR), augmentation pressure (AP), and augmentation index (AI) are notably higher in peripheral arterial disease (PAD), according to a study published in Medicine.

In this study, researchers sought to assess the association of several parameters determined by Mobil-O-graph, such as central blood pressure, brachial blood pressure, aortic PWV (aPWV), total vascular resistance (TVR), augmentation pressure (AP), and augmentation index (AI), with PAD.

This study consisted of 243 consecutive patients (67% PAD, and 33% non-PAD) from September 2016 to June 2019, were registered. Parameters, such as brachial BP, central BP, aortic pulse wave velocity (aPWV), total vascular resistance (TVR), augmentation index (AI) and augmentation pressure (AP), were discerned using Mobil-O-Graph. Ankle-brachial pressure index (ABI) was used to define PAD (ABI ≤ 0.9 as PAD), the researchers noted.

According to the results, in PAD group, the systolic brachial BP and central systolic BP were significantly higher than those in the non-PAD group. The researchers observed that TVR, AI, and AP were significantly higher in the PAD group. The researchers did not discern significant differences in diastolic BP, central diastolic BP, and aPWV between the groups. Overall, the study found that PAD was appreciably linked with TVR, AI, and AP.

The researchers identified several study limitations. Firstly, because the study was conducted in a single institution, the study population pool was smaller. Secondly, as the researchers noted, since all participants were referred to our hospital to be suspicious for PAD, the background of all participants were bias. Thirdly, because this analysis was cross-sectional observational in design, the effect of the interventional treatments for PAD on the changes in these parameters were not clarified. Fourth, PAD was defined only by ABI value, which alone cannot provide a precise clinical diagnosis of PAD.  Lastly, ABI value was determined by the oscillometric method, not by the doppler method. “Future study will be required to further confirm whether TVR/AP/AI are valuable markers for PAD,” the researchers wrote of the limitations.

“TVR, AP, and AI were significantly higher in the PAD group than in the non-PAD group. Non-invasive, easy, and reproducible tool is desirable to assess arterial stiffness,” the researchers concluded.