Rob Dillard

DocwireNews

Total vascular resistance (TVR), augmentation pressure (AP), and augmentation index (AI) are notably higher in <a href="https://www.docwirenews.com/docwire-pick/cardiology-picks/coagulation-factor-activity-may-be-linked-to-pad-complications/">peripheral arterial disease</a> (PAD), according to a study <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360418/">published</a> in Medicine.In this study, researchers sought to assess the association of several parameters determined by Mobil-O-graph, such as central blood pressure, brachial blood pressure, aortic PWV (aPWV), total vascular resistance (TVR), augmentation pressure (AP), and augmentation index (AI), with PAD.This study consisted of 243 consecutive patients (67% PAD, and 33% non-PAD) from September 2016 to June 2019, were registered. Parameters, such as brachial BP, central BP, aortic pulse wave velocity (aPWV), total vascular resistance (TVR), augmentation index (AI) and augmentation pressure (AP), were discerned using Mobil-O-Graph. Ankle-brachial pressure index (ABI) was used to define PAD (ABI&#8202;&le;&#8202;0.9 as PAD), the researchers noted.According to the results, in PAD group, the systolic brachial BP and central systolic BP were significantly higher than those in the non-PAD group. The researchers observed that TVR, AI, and AP were significantly higher in the PAD group. The researchers did not discern significant differences in diastolic BP, central diastolic BP, and aPWV between the groups. Overall, the study found that PAD was appreciably linked with TVR, AI, and AP.The researchers identified several study limitations. Firstly, because the study was conducted in a single institution, the study population pool was smaller. Secondly, as the researchers noted, since all participants were referred to our hospital to be suspicious for PAD, the background of all participants were bias. Thirdly, because this analysis was cross-sectional observational in design, the effect of the interventional treatments for PAD on the changes in these parameters were not clarified. Fourth, PAD was defined only by ABI value, which alone cannot provide a precise clinical diagnosis of PAD.&nbsp; Lastly, ABI value was determined by the oscillometric method, not by the doppler method. &ldquo;Future study will be required to further confirm whether TVR/AP/AI are valuable markers for PAD,&rdquo; the researchers wrote of the limitations.&ldquo;TVR, AP, and AI were significantly higher in the PAD group than in the non-PAD group. Non-invasive, easy, and reproducible tool is desirable to assess arterial stiffness,&rdquo; the researchers concluded.

Bradley Marder, MD

Joel M. Topf, MD, FACP

Gout Studies: Transplant Waitlisting and Bone Erosion

NKF Spring Clinical Meetings 2025

Jayme Locke, MD, MPH

The Promise of Xenotransplantation

Leah Lawrence

Real-World Data Backs Invasive DFS as Surrogate Endpoint for OS in EBC

HR Breast Cancer

Latest News

Mobil-O-Graph Monitor Identifies Several Parameters Linked with PAD

Atherosclerotic Disease

Total vascular resistance (TVR), augmentation pressure (AP), and augmentation index (AI) are notably higher in peripheral arterial disease (PAD), according to a study ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HER2 Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe