Rebecca Araujo

DocwireNews

It remains questionable as to whether peripheral artery disease (PAD) leads to remote ischemic preconditioning (RIPC) after endovascular thrombectomy (EVT).A team of Dutch researchers established the prospective MR CLEAN registry to compare EVT outcomes in acute stroke patients with and without PAD.&ldquo;Though PAD is a well-known risk factor for ischemic events, better outcomes have been described in acute ischemic stroke patients with co-existing PAD,&rdquo; the authors wrote. &ldquo;This paradoxical association has been attributed to remote ischemic preconditioning (RIPC) and might be related to better collateral blood flow.&rdquo;The investigators looked at 2,765 patients treated with EVT for an anterior large artery occlusion, of which 9.2% participants (n=254) had PAD. Collaterals were scored on a 4-point scale using computed tomography (CT) angiography. The primary outcome was the association of PAD with collateral grades and functional outcome at 90 days, assessed via the modified Rankin Scale (mRS). Other safety outcomes included mortality at 90 days, symptomatic intracranial hemorrhage, and stroke progression.After adjustment for confounding factors, a multivariable regression analysis found no association of PAD with functional outcome (mRS cOR 0.90, 95% confidence interval [CI], 0.7&ndash;1.2), collateral grades (cOR 0.85, 95% CI 0.7&ndash;1.1), or safety outcomes. There was also no association established between PAD and other secondary outcomes.&ldquo;In summary, our study showed no association between PAD and outcome after EVT for acute ischemic stroke nor an independent association between PAD and collateral blood flow,&rdquo; the authors wrote in their conclusion. &ldquo;As such, we could not confirm the occurrence of RIPC in PAD patients with acute <a href="https://www.docwirenews.com/docwire-pick/cardiology-picks/stroke-treatment-time-improvement/">ischemic stroke</a>. Future studies with more standardized measurement of PAD are recommended.&rdquo;The paper was published in <a href="https://www.frontiersin.org/articles/10.3389/fneur.2020.560300/full">Frontiers in Neurology</a>.

Eric Bergson, MD

Rob Dillard

The Role of Multidisciplinary Care in Head and Neck Cancer

Head and Neck Cancer

Sara Nunnery, MD, MSCI

Trastuzumab Deruxtecan in HER2-Low Breast Cancer: Who’s the Right Patient?

HER2 Breast Cancer

Meghan Sise, MD

Joel M. Topf, MD, FACP

Redefining Carboplatin Dosing

NKF Spring Clinical Meetings 2025

Latest News

No Significant Association Between PAD and Outcomes After Endovascular Thrombectomy

Atherosclerotic Disease

It remains questionable as to whether peripheral artery disease (PAD) leads to remote ischemic preconditioning (RIPC) after endovascular thrombectomy (EVT). ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HR Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe