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Researchers, led by Shima Yazdandoust, sought to uncover associations between high-density lipoprotein lipid peroxidation (HDLox) levels and <a href="https://www.docwirenews.com/docwire-pick/high-density-lipoprotein-mimetic/">coronary artery disease</a> (CAD) via coronary angiography. Their study, published in Biofactors, found that the oxidation of high-density lipoprotein (HDL) &ldquo;leads to a reduction in its antioxidant function,&rdquo; and plays a significant role in the development of atherosclerosis.The study included a total of 572 patients with stable CAD plus 281 healthy subjects with no history of <a href="https://www.docwirenews.com/cardiology/hepatic-overexpression-of-endothelial-lipase-lowers-high-density-lipoprotein-but-maintains-reverse-cholesterol-transport-in-micehighlights-basic-sciences/">cardiovascular disease</a> as a control group. Patients with CAD were divided into CAD&ndash; and CAD+ positive groups using coronary angiography. The researchers used a fluorimetric method to measure HDLox levels. They also assessed how effectively HDLox and serum HLD cholesterol could detect and coronary artery stenosis of &ge;50% with a receiver operating characteristic (ROC) curve analysis.The investigators observed significantly higher serum HDLox levels in patients with CAD compared to the control group (1.15 [range: 1.01&ndash;1.31] vs. 0.85 [range: 0.62&ndash;1.06]; p &lt;0.001). Furthermore, CAD&ndash; patients had significantly lower HDLox levels compared to CAD+ patients (1.05 [range: 0.92&ndash;1.22] vs. 1.24 [range: 1.12&ndash;1.35]; p &lt;0.001). Based on their ROC analysis, the authors suggested that HDLox was better at detecting the risk of CAD and coronary artery stenosis versus serum HDL cholesterol levels.Overall, the study&rsquo;s collaborators identified a key mechanism of high-density lipoprotein oxidation leading to poorer prognoses, and ultimately recommended that HDLox be used as a diagnostic biomarker for CAD.

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High-Density Lipoprotein Peroxidation as a Predictive Biomarker in Coronary Artery Disease

Atherosclerotic Disease

Researchers, led by Shima Yazdandoust, sought to uncover associations between high-density lipoprotein lipid peroxidation (HDLox) levels and coronary artery disease (CAD) via ...

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