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The Martin/Hopkins method of LDL-C estimation provided values&nbsp;closer to the gold standard of estimation than the&nbsp;Friedewald&nbsp;estimation method in patients achieving lower LDL-C with PCSK9&nbsp;inhibition, results of a new analysis of FOURIER patients revealed (which included 27,564 patients with stable atherosclerotic cardiovascular disease). The analysis, published recently in&nbsp;JAMA Cardiology,&nbsp;looked at LDL-C levels obtained in the trial as calculated by the&nbsp;Friedewald&nbsp;method and the Martin/Hopkins method, with the gold standard of&nbsp;preparative ultracentrifugation (PUC) used as a reference.&nbsp;&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
What is the accuracy of low-density lipoprotein <a href="https://twitter.com/hashtag/cholesterol?src=hash&amp;ref_src=twsrc%5Etfw">#cholesterol</a> (LDL-C) by Martin/Hopkins vs Friedewald estimation in patients achieving low LDL-C? Find out from <a href="https://twitter.com/SethShayMartin?ref_src=twsrc%5Etfw">@SethShayMartin</a> <a href="https://t.co/t330Pwtz7j">https://t.co/t330Pwtz7j</a> <a href="https://t.co/XS8MQGXSZF">pic.twitter.com/XS8MQGXSZF</a>
&mdash; JAMA Cardiology (@JAMACardio) <a href="https://twitter.com/JAMACardio/status/1006974497851887616?ref_src=twsrc%5Etfw">June 13, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><h3>Fourier Study Results</h3>According to the results of the analysis, 22.9% of the LDL-C values calculated via Martin/Hopkins method were greater than&nbsp;5 mg/dL&nbsp;of the PUC gold standard, with 2.6% varying by more than 10 mg/dL. This was less than those values obtained by the&nbsp;Friedewald&nbsp;method (40.1% and 13.3% respectively). The&nbsp;Friedewald&nbsp;method, the researchers concluded, tended to underestimate LDL-C level compared with the gold standard, resulting in possible undertreatment.&nbsp;&nbsp;&ldquo;These data suggest that Martin/Hopkins estimation should be the preferred method to estimate LDL-C levels in such intensively treated patients,&rdquo; they authors write. More reaction below:&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
What is the accuracy of low-density lipoprotein <a href="https://twitter.com/hashtag/cholesterol?src=hash&amp;ref_src=twsrc%5Etfw">#cholesterol</a> (LDL-C) by Martin/Hopkins vs Friedewald estimation in patients achieving low LDL-C? Find out from <a href="https://twitter.com/SethShayMartin?ref_src=twsrc%5Etfw">@SethShayMartin</a> <a href="https://t.co/t330Pwtz7j">https://t.co/t330Pwtz7j</a> <a href="https://t.co/XS8MQGXSZF">pic.twitter.com/XS8MQGXSZF</a>
&mdash; JAMA Cardiology (@JAMACardio) <a href="https://twitter.com/JAMACardio/status/1006974497851887616?ref_src=twsrc%5Etfw">June 13, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet" data-cards="hidden" data-lang="en">
In pts achieving low LDL-C w/PCSK9 inhibition, Martin/Hopkins method for LDL-C more closely approximates gold standard preparative ultracentrifugation than Friedewald. Martin/Hopkins may prevent undertreatment because of LDL-C underestimation by Friedewald <a href="https://t.co/ThHtdmvM6q">https://t.co/ThHtdmvM6q</a>
&mdash; rodolfo catanho (@rocatanho) <a href="https://twitter.com/rocatanho/status/1008197050205396992?ref_src=twsrc%5Etfw">June 17, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
We do direct LDL <a href="https://twitter.com/ThePLC?ref_src=twsrc%5Etfw">@ThePLC</a> but this is seminal work showing the fallacy and false sense of calculated LDL by the majority of labs in the US. Optimizing LDL therapy with a true measurement is key to reducing CV risk <a href="https://t.co/8WLWLB8Olp">https://t.co/8WLWLB8Olp</a>
&mdash; Dr. John A Rumberger, PhD, MD, FACC, MSCCT (@DrRumberger) <a href="https://twitter.com/DrRumberger/status/1007391771540754432?ref_src=twsrc%5Etfw">June 14, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>Source: <a href="https://jamanetwork.com/journals/jamacardiology/fullarticle/2684503">JAMA Cardiology</a>&nbsp;

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FOURIER Insights: What is the Accuracy of the Martin/Hopkins LDL-C Estimation?

Lipid Management

The Martin/Hopkins method of LDL-C estimation provided values closer to the gold standard of estimation than the Friedewald estimation method in patients achieving lower ...

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