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Genetic testing in young&nbsp;<a href="https://proddocwire.wpengine.com/orthopedic-surgery/an-athletes-sex-matters-in-sports-related-injuries-and-treatment-outcomes/">athletes</a>&nbsp;with T-wave inversion provided no diagnostic advantage beyond clinical&nbsp;evaluation, results from a new study in&nbsp;Circulation&nbsp;indicate.&nbsp;The authors investigated 50 consecutive black patients and 50 consecutive white patients (aged 14 to 35) with T-wave inversion who referred for&nbsp;<a href="https://proddocwire.wpengine.com/docwire-pick/genome-sequencing-hypertrophic-cardiomyopathy/">cardiomyopathy</a>&nbsp;and sports cardiology. Participants&nbsp;underwent&nbsp;exercise testing, ambulatory ECG, cardiac MRI and blood-based analysis of a 311-gene panel for cardiomyopathies and ion channel disorders related to T-wave inversion (including hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, dilated cardiomyopathy, left ventricular noncompaction, long-QT syndrome, and&nbsp;<a href="https://proddocwire.wpengine.com/electrophysiology-condition-center/propofol-for-implantable-cardioverter-defibrillator-implantation-in-patients-with-brugada-syndrome/">Brugada syndrome</a>).<a href="https://twitter.com/Prof_MatWilson/statuses/996707425964183553">https://twitter.com/Prof_MatWilson/statuses/996707425964183553</a>According to the results, 21 patients were diagnosed with cardiac disease by clinical investigations, 8 of whom were gene positive and 13 of whom were gene negative. Of the remaining athletes, 79 were gene positive in the absence of a clinical phenotype.&nbsp;Newly diagnosed&nbsp;cardiomyopathy&nbsp;prevalence was higher in white athletes compared to black athletes (P=0.027), and hypertrophic cardiomyopathy accounted for 90.5% of all diagnoses.&nbsp;&nbsp;&ldquo;Up to 10% of athletes with TWI revealed mutations capable of causing cardiac disease,&rdquo; the authors write in their conclusion. &ldquo;Despite the substantial cost, the positive diagnostic yield from genetic testing was one half that from clinical evaluation (10% versus 21%) and contributed to additional diagnoses in only 2.5% of athletes with TWI in the absence of a clear clinical phenotype, making it of negligible use in routine clinical practice.&rdquo;&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Some answered questions to the cardiac assessment for athletes with <a href="https://twitter.com/hashtag/TWI?src=hash&amp;ref_src=twsrc%5Etfw">#TWI</a>, great paper coming from <a href="https://twitter.com/SSharmacardio?ref_src=twsrc%5Etfw">@SSharmacardio</a> team <a href="https://twitter.com/Aspetar?ref_src=twsrc%5Etfw">@Aspetar</a> team @_healthincode et al. So good being part of it! <a href="https://twitter.com/nabeelsheikh99?ref_src=twsrc%5Etfw">@nabeelsheikh99</a> deserves recognition for hard and long work on this <a href="https://twitter.com/CircAHA?ref_src=twsrc%5Etfw">@CircAHA</a> <a href="https://t.co/04eIckQWzf">https://t.co/04eIckQWzf</a>
&mdash; Carmen Adamuz (@AdamuzC) <a href="https://twitter.com/AdamuzC/status/996779171916345345?ref_src=twsrc%5Etfw">May 16, 2018</a>
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Watch out, the pendulum is swinging the other way for EP genetics &ndash; "genetic testing &hellip; contributed to additional diagnoses in only 2.5% of athletes with [T wave inversion] &hellip; negligible use in routine clinical practice." <a href="https://t.co/dETVWsF8KQ">https://t.co/dETVWsF8KQ</a>
&mdash; Joel A. Kirsh, MD, MHCM (@joelakirsh) <a href="https://twitter.com/joelakirsh/status/1042598174471278592?ref_src=twsrc%5Etfw">September 20, 2018</a>
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Excellent <a href="https://twitter.com/hashtag/cryresearch?src=hash&amp;ref_src=twsrc%5Etfw">#cryresearch</a> by <a href="https://twitter.com/SSharmacardio?ref_src=twsrc%5Etfw">@SSharmacardio</a> <a href="https://twitter.com/nabeelsheikh99?ref_src=twsrc%5Etfw">@nabeelsheikh99</a> demonstrating why there needs to be caution when using <a href="https://twitter.com/hashtag/genetics?src=hash&amp;ref_src=twsrc%5Etfw">#genetics</a> in routine clinical practice when testing for <a href="https://twitter.com/hashtag/cardiomyopathy?src=hash&amp;ref_src=twsrc%5Etfw">#cardiomyopathy</a> &ndash; <a href="https://twitter.com/CRY_UK?ref_src=twsrc%5Etfw">@CRY_UK</a> <a href="https://t.co/T6kHwUFV2U">https://t.co/T6kHwUFV2U</a> <a href="https://t.co/jprVCgYCgG">https://t.co/jprVCgYCgG</a>
&mdash; Dr Steven Cox (@Drstevenjcox) <a href="https://twitter.com/Drstevenjcox/status/997111202416242689?ref_src=twsrc%5Etfw">May 17, 2018</a>
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Congratulations <a href="https://twitter.com/nabeelsheikh99?ref_src=twsrc%5Etfw">@nabeelsheikh99</a> <a href="https://twitter.com/MichaelPapadak2?ref_src=twsrc%5Etfw">@MichaelPapadak2</a> <a href="https://twitter.com/AdamuzC?ref_src=twsrc%5Etfw">@AdamuzC</a> <a href="https://twitter.com/DrAneilMalhotra?ref_src=twsrc%5Etfw">@DrAneilMalhotra</a> <a href="https://twitter.com/SSharmacardio?ref_src=twsrc%5Etfw">@SSharmacardio</a> &amp; coll of <a href="https://twitter.com/StGeorgesUni?ref_src=twsrc%5Etfw">@StGeorgesUni</a> for this other piece of the puzzle <a href="https://twitter.com/hashtag/genetics?src=hash&amp;ref_src=twsrc%5Etfw">#genetics</a> <a href="https://twitter.com/hashtag/athletes?src=hash&amp;ref_src=twsrc%5Etfw">#athletes</a> <a href="https://twitter.com/hashtag/sportCardiology?src=hash&amp;ref_src=twsrc%5Etfw">#sportCardiology</a> <a href="https://twitter.com/hashtag/EAPC?src=hash&amp;ref_src=twsrc%5Etfw">#EAPC</a> <a href="https://twitter.com/DrJTriasDeBes?ref_src=twsrc%5Etfw">@DrJTriasDeBes</a> <a href="https://twitter.com/FlavioDascenzi?ref_src=twsrc%5Etfw">@FlavioDascenzi</a> <a href="https://twitter.com/DOCTORASANZM?ref_src=twsrc%5Etfw">@DOCTORASANZM</a> <a href="https://twitter.com/paolo_emilio?ref_src=twsrc%5Etfw">@paolo_emilio</a> <a href="https://twitter.com/LSerratosa?ref_src=twsrc%5Etfw">@LSerratosa</a> <a href="https://twitter.com/Chrigi_Schmied?ref_src=twsrc%5Etfw">@Chrigi_Schmied</a> <a href="https://t.co/6kEBxGbHus">https://t.co/6kEBxGbHus</a>
&mdash; Silvia Castelletti (@SilCastelletti) <a href="https://twitter.com/SilCastelletti/status/1042657678030499840?ref_src=twsrc%5Etfw">September 20, 2018</a>
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Nice Circ paper in the genetics of cardiomyopathy in athletes&hellip; it is worth to screen! <a href="https://twitter.com/MichaelPapadak2?ref_src=twsrc%5Etfw">@MichaelPapadak2</a> <a href="https://twitter.com/nabeelsheikh99?ref_src=twsrc%5Etfw">@nabeelsheikh99</a> <a href="https://t.co/fJOZf1Z8cG">https://t.co/fJOZf1Z8cG</a>
&mdash; Vass Vassiliou (@vass_vassiliou) <a href="https://twitter.com/vass_vassiliou/status/996708886584397825?ref_src=twsrc%5Etfw">May 16, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>Source:&nbsp;<a href="https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.034208">Circulation</a>

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No Diagnostic Yield from Genetic Screening for Young Athletes with T-Wave Inversion

Cardiology

Genetic testing in young athletes with T-wave inversion provided no diagnostic advantage beyond clinical evaluation, results from a new study in Circulation indicate.  ...