Patrick Daly

DocwireNews

In a clinical trial published in Circulation: Heart Failure, researchers investigated outcomes of cryoballoon ablation in patients with atrial fibrillation and concurrent heart failure with preserved ejection fraction (HFpEF). According to the study&rsquo;s lead author, Maura Zylla, MD, this population had a distinct increased risk for atrial fibrillation recurrence after ablation compared with patients without HFpEF.The study included 102 prospective patients with left ventricular ejection fraction &ge;50% undergoing cryoballoon <a href="https://www.docwirenews.com/docwire-pick/steerable-versus-non-steerable-sheaths-in-catheter-ablation-for-af/">ablation</a>. Of those patients, 24 also had HFpEF. Researchers evaluated participants via echocardiography, stress echocardiography, a 6-minute walk test, biomarkers, and a quality-of-life questionnaire. The trial&rsquo;s primary end point was differences in procedure parameters and clinical outcomes between patients with or without HFpEF.<h3>Atrial Fibrillation With HFpEF Subgroup Has Worse Ablation Outcomes Versus General Population</h3>Compared with patients without HFpEF, patients with HFpEF were older (median years of age, 74 vs 65; P=.001), more often female (83% vs 28%; P&lt;.001), had more prominent atrial fibrillation-related symptoms (median European Heart Rhythm Association score, 3 vs 2; P&lt;.001), higher left atrial pressures (median mm Hg, 14 vs 10; P=.008), reduced left atrial-appendage velocity (median cm/s, 36 vs 59; P&lt;.001), and reduced 6-minute walk test distance (median distance in meters, 488 vs 539; P&lt;.001).Patients with HFpEF also had more frequent atrial fibrillation recurrence (57% vs 23%; P=.003), repeat ablation procedure (39% vs 14%), and atrial fibrillation-related rehospitalization (26% vs 7%; P=.016). The researchers also noted that heightened cardiac biomarkers and symptoms of heart failure persisted during follow-up, even in patients with successful rhythm control.Overall, Zylla and colleagues concluded that patients with atrial fibrillation with HFpEF constitute a distinct subgroup with higher recurrence risk and persistent heart failure symptoms after <a href="https://medlineplus.gov/ency/article/007368.htm">cryoballoon ablation</a> versus those without HFpEF. They suggested that &ldquo;future research is needed to optimize treatment strategies in patients with HFpEF.&rdquo;Find Related <a href="https://www.docwirenews.com/atrial-fibrillation/">Articles and Interviews at the Atrial Fibrillation Knowledge Hub</a>

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Cryoballoon Ablation in Atrial Fibrillation Plus HFpEF

Atrial Fibrillation

In a clinical trial published in Circulation: Heart Failure, researchers investigated outcomes of cryoballoon ablation in patients with atrial fibrillation and concurrent ...

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