Dr. Timothy Yap discusses the PETRA trial, which showed the efficacy of saruparib in treating HER2-negative breast cancer. Soft tumor environments can cause triple-negative breast cancer to spread more aggressively. Patients ≥70 years of age were more likely to have a reduction in their palbociclib dosage. Decreasing the at-home dose of dexamethasone before paclitaxel treatment may help reduce the incidence of infusion reactions. Dr. Samilia Obeng-Gyasi discusses how social factors can impact outcomes in breast cancer patients. For women with BRCA1 sequence variations, MRI surveillance is linked to lower breast cancer mortality. A study found a "substantial deficit" of undiagnosed cancer cases during the COVID-19 pandemic. Completing HBOT appears effective at reducing pain and fibrosis in patients with irradiated breast cancer. A researcher is looking to prove that nebivolol, an FDA-approved drug for high blood pressure, is effective at treating TNBC. Screening and new treatments have led to a US breast cancer mortality rate that is 58% lower than in it was in the mid-1970s. The FDA recently approved a new combination therapy for the treatment of HR-positive, HER2-negative breast cancer. CNS radiotherapy with pyrotinib and capecitabine improves CNS progression in breast cancer patients with brain metastases. The Oncology Brothers talk with Paolo Tarantino, MD, about the TROPiCS-02 study presented at SABCS. Will HER2CLIMB-02 study data impact the breast cancer landscape? For patients with breast cancer, a regimen of epirubicin followed by adjuvant chemotherapy is associated with worse QOL. Drs. Vishwas Paralkar and Sophia Gayle discuss CBX-15, a novel therapy for triple-negative breast cancer. Dan Forche, CEO of PreludeDx, a leader in precision medicine for early-stage breast cancer, discusses DCISionRT. Kaele Leonard, a pulmonary/critical care fellow who was diagnosed with breast cancer at a young age, discusses her journey. The Fellow on Call: The Heme/Onc Podcast covers HER2-positive breast cancer in part 11 of its series on breast cancer types. The Fellow on Call: The Heme/Onc Podcast switches from localized breast cancers to metastatic subtypes, starting with ER+.