Each week on DocWire News, editors bring you the latest hematology and oncology news and research. In case you missed it, here are this week’s top headlines:
- Telemedicine in Oncology: RT Patients Report High Satisfaction
- Taxane-Containing Chemo Associated With Persistent Alopecia
- ASA: Dexamethasone Use During Cancer Surgery May Reduce Mortality
- Lung Cancer Treatment May Impact Daily Function in Older Adults
Keep reading for the breakdown on these top stories.
Telemedicine in Oncology: RT Patients Report High Satisfaction
Taxane-Containing Chemo Associated With Persistent Alopecia
Persistent chemotherapy-induced alopecia is more severe in patients who receive a taxane-containing chemotherapy for breast cancer, but a significant proportion of patients see improvement in hair density with standard alopecia treatments, according to a study in JAMA Dermatology.
The researchers report that most patients had diffuse nonscarring alopecia (39%), female pattern hair loss (55%), or male pattern hair loss (six patients). Cicatricial alopecia was seen in six patients. Most patients underwent taxane-containing regimens (92%), which were associated with more severe alopecia versus regimens not containing taxanes. The majority of patients (88%) had trichoscopic signs indistinguishable from those of androgenetic alopecia. Histopathological features were also characteristic of androgenetic alopecia. Hair density improved with both topical and oral minoxidil, sometimes combined with antiandrogen therapy.
ASA: Dexamethasone Use During Cancer Surgery May Reduce Mortality
Administration of dexamethasone during cancer surgery for prevention of nausea and vomiting after surgery is associated with reduced 90-day mortality, according to a study presented at the annual meeting of the American Society of Anesthesiologists.
The researchers found that 0.83% and 3.2% of the patients who received dexamethasone and who did not receive dexamethasone, respectively, died within 90 days after surgery. Intraoperative administration of dexamethasone was associated with a reduced risk for 90-day mortality after adjustment for a priori defined covariates including patient demographics, comorbidities, and intraoperative factors (adjusted odds ratio, 0.68). In subgroup analyses, robust effects were seen for patients undergoing surgery for treatment of breast cancer and gynecologic malignancies of the reproductive organs (ovary, uterus, and cervix; adjusted odds ratios, 0.22 and 0.33, respectively).
Lung Cancer Treatment May Impact Daily Function in Older Adults
Older adults with lung cancer may experience declines in life-space mobility during treatment, according to a study published in the Journal of the American Geriatrics Society. The researchers found that on average, life-space assessment (LSA) declined 10.1 points from pretreatment to one month and remained stable at six months. There was an association between the pretreatment LSA score and several demographic, clinical, geriatric assessment, and symptom characteristics.
“Incorporating LSA into clinical cancer care may help older adults concretely visualize how treatment might impact their daily function to allow for informed decision making and identify early changes in mobility to implement supportive interventions,” the authors write.