Hem/Onc Roundup: Childhood Brain Tumor Risk, End-of-Life Care for Ovarian Cancer, and More

Prenatal exposure to a wide variety of pesticides may be associated with the development of childhood brain tumors, according to a new study. Using data from the California Cancer Registry and the California Department of Pesticide Regulation’s Pesticide Use Reporting system, the investigators found associations between several central nervous system tumors in children and maternal residence within 4,000 meters of pesticide application.

Prenatal Exposure to Pesticides Linked to Childhood Brain Tumors

In other news, patients at high risk of melanoma who undergo routine skin cancer screening and education are more likely to be diagnosed with earlier stage melanomas. “Our results suggest that the screening and education provided in the National Cancer Institute Familial Melanoma Study may improve early detection of melanoma in melanoma-prone families,” said lead author Michael Sargen, MD.

High Risk Melanoma Patients Can Benefit from Routine Screening and Education

Body weight may impact chemotherapy outcomes for children and adolescents being treated for acute lymphoblastic leukemia, according to a study published in Blood Advances. Youth who are obese when they begin chemotherapy are more than twice as likely to have remaining cancer cells after one month of treatment–and an increased chance of disease relapse–compared to their lean counterparts.

A Combination of Diet, Exercise, and Chemo Can Benefit Children Battling Acute Lymphoblastic Leukemia

Contrary to clinical guidelines, women with ovarian cancer continue to receive aggressive end-of-life care, with non-white women disproportionately affected. According to a study published in Cancer, during the last month of life women were much more likely to be admitted to the ICU and have multiple ED visits. Black women had much higher odds of having multiple ED visits and undergoing life-extending procedures than non-Hispanic white women.

End-of-life Care in Ovarian Cancer Remains Aggressive—Especially for Women of Color