Venous Thromboembolism in Sickle Cell Disease is Associated with Neutrophilia

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Hemoglobin. 2021 Feb 15:1-8. doi: 10.1080/03630269.2020.1869565. Online ahead of print.


Venous thromboembolism (VTE) in individuals with sickle cell disease is common and portends a poor prognosis. The role of leukocyte count and its subsets on risk of VTE in sickle cell disease are not known. We conducted a retrospective case-control study and analyzed for leukocyte count at the time of VTE and 3 months prior. Leukocyte and neutrophil counts were elevated at the time of VTE (p = 0.003 and p = 0.0006, respectively) and 3 months prior (p = 0.001 and p = 0.0096, respectively) when compared to controls. Baseline leukocytosis and neutrophilia may be associated with subsequent risk for thrombosis in sickle cell disease.

PMID:33588667 | DOI:10.1080/03630269.2020.1869565