Carcinogenesis. 2021 Apr 30:bgab033. doi: 10.1093/carcin/bgab033. Online ahead of print.
Ovarian cancer (OC) is known to be the most lethal cancer in women worldwide and its etiology is poorly understood. Recent studies show that mitochondrial DNA (mtDNA) content as well as mtDNA and nuclear genes encoding mitochondrial proteins influence OC risk. This review presents an overview of role of mitochondrial genetics in influencing OC development and discuss the contribution of mitochondrial proteome in OC development, progression and therapy. A role of mitochondrial genetics in racial disparity is also highlighted. In-depth understanding of role of mitochondria in OC will help develop strategies towards prevention and treatment and improving overall survival in women with OC.