Chest. 2020 Nov 17:S0012-3692(20)35155-2. doi: 10.1016/j.chest.2020.11.010. Online ahead of print.
BACKGROUND: Prior reports on a possible female survival advantage in both surgical and non-surgical cohorts of patients with lung cancer are conflicting. Previously reported differences in survival following lung cancer surgery could be due to insufficient control for disparities in risk factor profile in men and women.
RESEARCH QUESTION: Do women who undergo pulmonary resections for lung cancer have a better prognosis than men, when taking a wide range of prognostic factors into account?
DESIGN AND METHODS: We performed a nationwide population-based observational cohort study analyzing sex-specific survival after pulmonary resections for lung cancer. We identified 6356 patients from the Swedish national quality register for general thoracic surgery and performed individual-level record linkage to other national health-data registers to acquire detailed information regarding comorbidity, socioeconomic status, and vital status. Inverse probability of treatment weighting was used to account for differences in baseline characteristics. The association between female sex and all-cause mortality was assessed with Cox regression models, and flexible parametric survival models was used to estimate the absolute survival differences with 95% confidence intervals (CI). We also estimated the difference in restricted mean survival time.
RESULTS: We observed a lower risk of death in women compared with men (HR, 0.73; 95% CI, 0.67-0.79). The absolute survival difference (95% CI) at 1, 5, and 10 years was 3.0% (2.2%-3.8%), 10% (7.0%-12%), and 12% (8.5%-15%), respectively. The restricted mean survival time difference at 10 years (95% CI) was 0.84 (0.61-1.07) years. The findings were consistent across several subgroups.
INTERPRETATION: Women who underwent pulmonary resections for lung cancer had significantly better prognosis than men. The survival advantage was evident regardless of age, common comorbidities, socioeconomic status, lifestyle factors, physical performance, type and extent of surgery, tumor characteristics and stage.