Reduction of Severe Acute Respiratory Syndrome Coronavirus-2 Infectivity by Admissible Concentration of Ozone Gas and Water

Microbiol Immunol. 2020 Nov 24. doi: 10.1111/1348-0421.12861. Online ahead of print.


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the global coronavirus disease 2019 (COVID-19) pandemic. Because complete elimination of SARS-CoV-2 appears difficult, decreasing the risk of transmission is important. Treatment with 0.1 and 0.05 ppm ozone gas for 10 and 20 h, respectively, decreased SARS-CoV-2 infectivity by about 95%. The magnitude of the effect was dependent on humidity. Treatment with 1 and 2 mg/L ozone water for 10 s reduced SARS-CoV-2 infectivity by about 2 and 3 logs, respectively. Our results suggest that low-dose ozone, in the form of gas and water, is effective against SARS-CoV-2. This article is protected by copyright. All rights reserved.

PMID:33230863 | DOI:10.1111/1348-0421.12861