Statins were linked with the slower overall progression of coronary atherosclerosis volume, results from a new study suggested. Researchers for the prospective PARADIGM looked at consecutive patients without history of coronary artery disease who underwent serial coronary computed tomography angiography to analyze plaque composition (n=1,255).
In a prospective, multi-national #coronary #CTA registry (PARADIGM), statins accelerated calcification of coronary atherosclerotic plaque & reduced development of high-risk plaque features: https://t.co/zsVOn5Kd93. #JACCIMG #cvCAD #Statin #prevmed pic.twitter.com/DRfyVaNiwY
— JACC Journals (@JACCJournals) June 29, 2018
The researchers evaluated a total of 1,079 coronary artery lesions in statin-naïve patients and in patients taking statins. Patients taking statins demonstrated slower overall percent atheroma volume progression (P=0.002), but also a more rapidly progressing calcified percent atheroma volume as well (P<0.001). They also reported lower progression of noncalcified percent atheroma volume and annual high-risk plaque in patients on statins (P<0.001). Statins were also associated with a reduction (21%) in annualized total percent atheroma volume progression above the median and a reduction (35%) in high-risk plaque development.
“Statins did not affect the progression of percentage of stenosis severity of coronary artery lesions but induced phenotypic plaque transformation,” the researchers added.
We all knew this was happening….but here is the evidence. Cardiac CT works in finding patients who then benefit from statin therapy. @CardiologySWBH @SWBHnhs @SWBHCharity https://t.co/CXBO2TDOsa
— Prof Derek Connolly (@DrDerekConnolly) June 30, 2018
More evidence for #statin effect on plaque calcium and stabilization. We showed this in the past in an #IVUS study too https://t.co/kHTtCQqOex@SCCT @FiRSTSCCT @lesleejshaw @DrPascalMeier @chadialraies @emoryheart @gina_lundberg @EpicSec @ACCCardioEd https://t.co/ydGANBFQdS
— Parham Eshtehardi MD (@CoronaryDoc) June 30, 2018
Source: JACC Cardiovascular Imaging
