Crohns Colitis 360. 2020 Sep 23;2(4):otaa073. doi: 10.1093/crocol/otaa073. eCollection 2020 Oct.
ABSTRACT
BACKGROUND: Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids.
METHODS: We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks.
RESULTS: The response rate of all patients was 58.2% (39/67). Of the 39 patients who achieved a response, 74.4% achieved endoscopically confirmed mucosal healing.
CONCLUSIONS: GMA shows effectiveness in inducing remission in UC patients not receiving steroid.
PMID:34192247 | PMC:PMC7797742 | DOI:10.1093/crocol/otaa073