A Novel Prognostic Risk Factor for Patients Undergoing Radical Prostatectomy: Triglyseride-Glucose (TyG) Index

Int J Clin Pract. 2021 Jan 1:e13978. doi: 10.1111/ijcp.13978. Online ahead of print.


BACKGROUND: Obesity and metabolic syndrome are growing health problems in western countries. Recently reported TyG index is reliable and accessible indicator of metabolic syndrome. TyG index could be used as a indicator of a prognostic risk factor for metabolic syndrome-related cancers.

OBJECTIVES: To investigate the prognostic role of TyG index on oncological outcomes in patients undergoing radical prostatectomy.

DESIGN, SETTING AND PARTICIPANTS: Data from 200 men who underwent radical prostatectomy were used.

OUTCOME MEASUREMENTS AND STATSITICAL ANALYSE: Triglyserid-Glucose index were calculated based on TyG index= Ln [TG (mg/dl) FPG (mg/dl)/2] formula. Patient divided into two groups according to the 8,55 level as cut-off value for TyG index. Laboratory results, oncological outcomes and survivals were comparised statistically between groups.

RESULTS: Mean ages of patients were 64.32±6.1 years and median follow-up time was 61.6±35 (range 4-140) month. Biochemical recurrens was observed in 42(21%) patients. Positive correlation between TyG index, body mass index, waist circumference, prostate biopsy gleason score, clinical T stage, positive surgical margin, pathological T stage and biochemical recurrence were observed. There was no statistical significance in terms of survival between groups.

CONCLUSION: Association between TyG index and prostate cancer may facilitate to predict unfavorable prognostic factors of radical prostatectomy. Increased TyG index may use as a predictive marker of positive surgical margin status before radical prostatectomy, BCR, advanced cT and pT stages after radical prostatectomy or worse biopsy gleason score in clinical practice.

PMID:33386661 | DOI:10.1111/ijcp.13978