Diabetes and CKD and Quality-of-Life

Chronic kidney disease (CKD) and diabetes are associated with deceased quality-of-life. The combined impact of having both diseases is less well known. Melanie L. R. Wyld, MBBS, MBA, MPH, and colleagues conducted a prospective, longitudinal cohort study to measure quality-of-life in patients with both CKD and diabetes. Results were reported in Nephrology Dialysis Transplantation [2021;36(6):1048-1056].

The study included community-based Australians ≥25 years of age who participated in the Australian Diabetes, Obesity and Lifestyle study. The physical component summary and mental component summary subscores of the Short Form (36) Health Survey were used to measure quality-of-life.

A total of 11,081 participants had quality-of-life measurements at baseline. Of those, 1112 had CKD, 1001 had diabetes, and 271 had both. Of the patients with CKD, 421 had CKD stage 1, 314 had stage 2, 346 had stage 3, and 31 had stages 4/5. Baseline physical component summary scores were lower for those with both CKD and diabetes than those with either disease alone (P<.001) in adjusted linear mixed effect models. In longitudinal analyses, there was a more rapid decline in physical component summary score in those with both diseases.

In conclusion, the researchers said, “The combination of CKD and diabetes has a powerful adverse impact on quality-of-life, and participants with both diseases had significantly poorer quality-of-life than those with one condition.”