NKF Spring Clinical Meetings 2021
There are few data available on the epidemiology of acute kidney injury (AKI), associated risk factors, treatments, and mortality rate among pediatric patients with COVID-19 admitted to the intensive care unit (ICU). AKI is a common and severe complication in children and adolescents with COVID-19, and an understanding of the disease will aid in development of treatment and preventative care strategies to reduce morbidity and mortality in that patient population.
Isabelle Mawby and colleagues conducted a study to examine the incidence of AKI among COVID-19 patients in pediatric ICUs in North American using the Virtual Pediatric Systems (VPS) database. The researchers also sought to assess COVID-19-related risk factors; treatments, including kidney replacement therapy (KRT); and mortality rates. Results of the analysis were reported during a virtual poster session at the NKF Spring Clinical Meetings 2021 in a poster titled Acute Kidney Injury in COVID-19 Pediatric Patients: Analysis of the Virtual Pediatric Systems Data.
The retrospective study included patients ≤24 years of age with COVID-19 in the VPS COVID-19 database who were admitted to the ICU between January 1, 2020, and June 30, 2020. The poster reported results of analysis of data on 1240 pediatric patients with COVID-19.
Of the 1240 patients, 172 had renal/urinary system involvement. Of those 172, there were 19 confirmed deaths, translating to 45% of all confirmed pediatric COVID-19 deaths associated with renal involvement. Of the 36 patients who required KRT, two died. An additional 264 (24.67%) patients were diagnosed with MIS-C (multisystem inflammatory syndrome in children).
In conclusion, the researchers said, “Although COVID-19 in the pediatric population tends to present more favorably, renal involvement among the pediatric COVID-19 population may be considered a negative prognostic factor with respect to patient outcomes.”
Source: Mawby I, Chakraborty R, Pandya A, Mahajan S, Raina R. Acute kidney injury in COVID-19 pediatric patients: Analysis of the virtual pediatric system data. Abstract of a poster presented at the virtual National Kidney Foundation Spring Clinical Meetings 2021 (Poster #16), April 9, 2021.