Study: Correlates Of M-value Differ Between Type 1 And Type 2 Diabetes

The researchers for his paper wanted to assess the different factors that affect the insulin-stimulated whole body glucose disposal (M-value) at the onset of type 1 or type 2 diabetes. The study included 132 patients with type-1 or type-2 diabetes and matched them for age, sex, and body mass index with known diabetes duration <12 months. The authors performed multivariable linear regression analyses to determine associations between glycemic control, blood lipids, adiponectin, pro-inflammatory immune mediators, and M-value. The results suggested lower mean M-value in patients with type 2 diabetes than in those with type-1 diabetes. Fasting blood glucose correlated negatively with M-value in both type-1 and type-2 diabetes. “Fasting glycemia correlate with insulin-stimulated glucose disposal in both diabetes types, while altered liver and adipose tissue function associate with insulin-stimulated glucose disposal only in type 2 diabetes, underpinning specific differences between these diabetes types,” the authors concluded.


Source: Simon MC, Moller-Horigome A, Strassburger K, et al. J Clin Endocrinol Metab. 2019;doi:10.1210/jc.2018-02057