Diabetes Prevention Program Successfully Reduces Risk

A recent study evaluated the outcomes of Healthier You: National Health Service Diabetes Prevention Program (NHS DPP), which the authors stated is “the largest DPP globally to achieve universal population coverage.” The program was implemented in adult patients with non-diabetic hyperglycemia (defined as hemoglobin A1c [HbA1c], 42 mmol/mol to 47 mmol/mol [6.0% to 6.4%] or fasting plasma glucose 5.9 mmol/L to 6.9 mmol/L) between June 2016 (when NHS DPP was launched) and December 2018. National service-level data were gathered from England. By the end of the study, 324,699 patients were referred, 152,294 attended the initial assessment, and 96,442 attended at least one of the 13 group-based intervention sessions. Allowing enough time to pass, 53% attended an initial assessment, 36% attended at least one group-based session, and 19% finished the whole intervention by attending more than 60% of the sessions. A total of 32,655 patients attended at least one intervention session and had enough time to finish, of whom more than half (n=17,252, 53%) finished. Upon intent-to-treat analysis, mean weight loss was 2.3 kg, and mean HbA1c reduction was 1.26 mmol/mol. Upon completer analysis, mean weight loss was 3.3 kg and mean HbA1c reduction was 2.04 mmol/mol. The following factors were associated with less weight loss: younger age, female sex, Asian and black ethnicity, lower socioeconomic status, and normal body mass index at baseline. Predictors of less HbA1c reduction were older age, female sex, black ethnicity, lower socioeconomic status, and baseline overweight and obesity.