Childhood Acute Pancreatitis Increases Eventual Diabetes Risk

In a new population-based study, researchers evaluated whether there was an association between a single resolved incident of childhood acute pancreatitis with eventual development of diabetes in adulthood. A total of 1,802,110 Israeli adolescents (mean age [range], 17.4 [16–20] years) were evaluated prior to compulsory military service between 1979 and 2008; patient data were linked to that of the Israeli National Diabetes Registry. The authors defined resolved pancreatitis as “a history of a single event of acute pancreatitis with normal pancreatic function at enrollment.” Patients with resolved pancreatitis were more likely than the non-pancreatitis participants to develop incident diabetes (4.6% [n = 13/281; none identified as type 1 diabetes] versus 2.5% [n = 44,463 versus 1,801,716]). When adjusting for age, sex, and birth year, resolved acute pancreatitis more than doubled the risk of incident diabetes (odds ratio [OR]=2.23; 95% CI, 1.25 to 3.98). In further analyses adjusting for baseline body mass index and sociodemographic factors, resolved acute pancreatitis was still associated with a twofold risk for incident diabetes (OR=2.10; 95% CI, 1.15 to 3.84). Patients with childhood pancreatitis were more likely to be diagnosed with diabetes at a younger age compared to non-pancreatitis patients (diabetes diagnosis age <40 years 92% versus 47%, P=0.002).