Researchers for this study, aiming to evaluate the performance of six different diagnostic indices for cardiac amyloidosis used during SPECT with 99mTc-HDMP scintigraphy, retrospectively reviewed scintigraphy of a study population of 76 patients undergoing diagnostic evaluation for the condition. ROC-analysis was performed for optimal cutoff in identifying patients with cardiac amyloidosis and stratifying according to Perugini score. According to the results, Heart/Whole-body ratios were the most accurate in identifying cardiac amyloidosis patients. Heart/Pelvis ratios had acceptable accuracy (98%). Heart/Contralateral Lung ratio was exposed to confounding background noise. Heart/Skull ratio had the worst performance. “Heart/Whole-body ratios may be robust and effective semi-quantitative indices for the evaluation of cardiac amyloidosis by means of scintigraphy,” the researchers wrote.
Read more in the Journal of Nuclear Cardiology: https://link.springer.com/article/10.1007%2Fs12350-019-01643-w