Neuro-cognitive system dysfunction and symptom sets: A review of fMRI studies in youth with conduct problems

Publication date: August 2018
Source:Neuroscience & Biobehavioral Reviews, Volume 91
Author(s): R.J.R. Blair, K. Veroude, J.K. Buitelaar
In this paper, we review fMRI work on neuro-cognitive systems that are considered to be dysfunctional in individuals with conduct problems (i.e., individuals with Conduct Disorder (CD), Oppositional Defiant Disorder (ODD) or antisocial behavior without formal clinical diagnosis). These are: empathy, the acute threat response, reinforcement-based decision-making, response inhibition and the Default Mode Network. Evidence regarding the Default Mode Network is somewhat inconsistent and its functional role/the symptom sets consequent on its dysfunction remain underspecified. However, dysfunctions in the other four neuro-cognitive systems are associated with symptom sets seen in individuals with conduct problems.