Advanced-Stage Kidney Cancer More Prevalent Among Hispanics and Native Americans

Renal cell carcinoma (RCC) risk is higher among Hispanic Americans and Native Americans than Whites, according to a recent study published in the journal Cancers.

In this study, researchers assessed RCC health disparities in American Indians/Alaska Natives (AIs/ANs) and Hispanic Americans (HAs) with respect to disease stage and mortality. Population data were obtained from the National Cancer Database (NCDB) and Arizona Cancer Registry (ACR). The researchers used Logistic and Cox regression analyses to gauge the effect of race/ethnicity on disease stage and mortality, adjusting for neighborhood socioeconomic factors, rural/urban residence pattern, and other factors.

According to the results, AIs/ANs had markedly increased odds of advanced-stage RCC. The researchers observed that Mexican Americans had higher odds of advanced-stage compared to non-Hispanic Whites, both naturally (OR=1.22, 95% CI, 1.11–1.35) and in Arizona (OR=2.02, 95% CI, 1.58–2.58), even after adjusting for neighborhood characteristics.

“We knew from our past research that Hispanic Americans and Native Americans have a heavier burden of kidney cancer than non-Hispanic whites,” said Ken Batai, PhD, a Cancer Prevention and Control Program research member at the UArizona Cancer Center and research assistant professor of urology in the College of Medicine – Tucson via a press release. “But we also know that around 90% of the Hispanic population in Arizona is Mexican American – either U.S.-born or Mexican-born – and we do not think this subgroup is well-represented in the national data.”


“Carefully documenting these disparities is something that distinguishes us as a comprehensive cancer center,” said Joann Sweasy, PhD, Cancer Center director and inaugural holder of the Nancy C. and Craig M. Berge Endowed Chair. “Dr. Batai is embedded in our center not only in prevention, but he is also a part of our genitourinary clinical research team. This research benefits both perspectives, which are critical for us to meet the needs of our patients.”