Type 2 Diabetes Worsens Renal Cell Carcinoma Outcomes

Renal cell carcinoma (RCC) patients with preexisting type 2 diabetes mellitus (T2DM) have worse survival and recurrence odds compared to non-diabetic patients. Between 2013 and 2018, 451 RCC patients underwent radical or partial nephrectomy at a single institution; 74 (16.4%) had T2DM. Patients with T2DM were older and had higher body mass index; smaller neoplasms; and higher hypertension, cardiovascular morbidity, and laparoscopic surgery rates. Compared to patients without T2DM, diabetic patients had shorter overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS). Fuhrman grade and T2DM were both OS predictors, and T2DM was an independent predictor of CSS and RFS. RFS in T2DM patients was not influenced by varying surgical techniques.

Source: Yang H, Yin K, Wang Y, et al. J Diabetes. 2019;doi: 10.1111/1753-0407.12957