Effects of Fat and Lean Body Mass on Cardiovascular Events in T2DM

Lean body mass and fat mass have been shown to impact the body differently, but their effects on cardiovascular events in patients with type 2 diabetes mellitus (T2DM) have not yet been explored. In this study, researchers analyzed data from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study to establish the correlation between predicted lean body mass or fat mass and major adverse cardiovascular events in T2DM patients. A major adverse cardiovascular event was defined as a composite of nonfatal myocardial infarction, nonfatal stroke, or cardiovascular-related death. Patients were stratified into sex-specific quartiles based on predicted lean body mass and fat mass. Final analysis included 10,251 patients, who were followed for a mean 8.8 years. During follow-up, 1,801 (17.8%) patients sustained a major adverse cardiovascular event. The incidence rate of cardiovascular events was 16.4% in the first quartile, 17.2% in the second, 17.5% in the third, and 19.8% in the fourth. Compared to those in the first quartile, the hazard ratio of a major adverse cardiovascular event in the fourth quartile patients was 1.53. The authors concluded that while fat mass raised the risk for major adverse cardiovascular events, increases in lean mass did not.

Source: Xing Z, Tang L, Chen J, et al. CMAJ. 2019; doi: 10.1503/cmaj.190124