According to a study published in Diabetes Care, variability in independent cardiovascular risk factors (CVRFs) in childhood may be predictive of development of diabetes in adulthood. A total of 1,718 patients were included. All patients had taken part in the Bogalusa Heart Study and underwent CVRF measurements at least four times between the ages of four and 19 years. They were followed for a mean 20.5 years. Regardless of the indices used, there was a significant, independent correlation between childhood variability in body mass index (BMI) or high-density lipoprotein cholesterol (HDL-C) and diabetes development later in life. In combined analyses, there was still an association between later life diabetes and high childhood BMI and HDL-C variability. The following CVRF variabilities, when adjusting for confounding variables, were not significantly tied to diabetes: systolic/diastolic blood pressure, total cholesterol, triglycerides, and low-density lipoproteins cholesterol.