Association Between Serum Cholesterol Levels and Diabetic Polyneuropathy

A prospective cohort study published in JAMA Network Open evaluated the relationship between diabetic polyneuropathy (DPN) and lowering serum cholesterol levels. Between June 1, 2015, and March 31, 2018, 100 patients (mean age, 64.6 years) underwent magnetic resonance neurography of the right leg. The primary outcome was lesion load and extension, and other outcomes included clinical, serologic, and electrophysiologic results. A positive correlation was associated between lipid equivalent lesion (LEL) load and the mean cross-sectional area of the nerve and the maximum lesion length. There was a negative association between LEL load and total serum cholesterol level, high-density lipoprotein cholesterol level. low-density lipoprotein cholesterol level, nerve conduction velocities of the tibial and peroneal nerves, and nerve conduction amplitudes of the tibial and peroneal nerves. The study authors concluded that a reduction in serum cholesterol levels in patients with type 2 diabetes mellitus (T2DM) and DPN is associated with more nerve lesions and reduced nerve conduction velocities and amplitudes.

Source: Jende JME, Groener JB, Rother C, et al. JAMA Netw Open. 2019;doi: 10.1001/jamanetworkopen.2019.4798