Effect of anti-MRSA Agent De-escalation in Culture-negative Nosocomial Pneumonia on Mortality

In this study, researchers analyzed whether anti-MRSA agent de-escalation in culture-negative nosocomial pneumonia impacts 28-day and hospital mortality, ICU and hospital length of stay (LOS), treatment failure, and safety outcomes. Patients had no differences in 28-day mortality whether they were de-escalated or not, but de-escalated patients had shorter hospital and ICU length of stays. Patients who were not de-escalated had significantly higher risk of acute kidney disease.

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