Investigational Immunotherapy Looks Positive for HPV-Related Epithelial Cancers

In this phase 1 study, eight patients with metastatic HPV-16 cancers received a single infusion of KITE-439. In six patients, the E7 TCR was expressed by 90% to 99% of the infused T cells, and E7 T cells were detectable in the peripheral blood six weeks after treatment.