What Came First: The Microbiota or the Tr(egg) Cells?

Publication date: 19 June 2018
Source:Immunity, Volume 48, Issue 6
Author(s): Tal Gefen, Naama Geva-Zatorsky
Studies have shown that gut commensals facilitate the differentiation of peripheral regulatory T cells (pTregs) via their metabolic products. In this issue of Immunity, Campbell et al. (2018) demonstrate a reciprocal effect of pTregs on the metabolic functions of specific gut commensals that affects their overall energy harvest capacity.

Teaser

Studies have shown that gut commensals facilitate the differentiation of peripheral regulatory T cells (pTregs) via their metabolic products. In this issue of Immunity, Campbell et al. (2018) demonstrate a reciprocal effect of pTregs on the metabolic functions of specific gut commensals that affects their overall energy harvest capacity.