Risk Factors for Depressive Symptoms Post-ICU with Mechanical Ventilation

About one in three patients treated in the intensive care unit (ICU) exhibit depressive symptoms one year following discharge, which adversely impacts patient outcomes. In this study, researchers identified risk factors for depressive symptoms one year after ICU discharge among patients who received at least seven days of mechanical ventilation. Data from the Rehabilitation and Recovery in Patients after Critical Illness and Their Family Caregivers (RECOVER) Program (phase I) were evaluated for associations between patient depressive symptoms (captured using the Beck Depression Inventory II [BDI-II]), patient characteristics (age, sex, socioeconomic status, Charlson Comorbidity Index score, and ICU length of stay [LOS]), functional independence measure (FIM) motor subscale score, and caregiver characteristics (Caregiver Assistance Scale and Center for Epidemiologic Studies-Depression Scale) at three, six, and 12 months. Final analysis included BDI-II data on 246 patients (median age at ICU admission, 56 years); 58% of patients were male. Median ICU LOS was 19 days (range, 13-32 days). Over the study period, 27.2% of patients (n=67) exhibited a BDI-II score ≥20, indicating moderate to severe depressive symptoms. The following factors were associated with depressive symptoms: lower FIM motor subscale scores (1.1 BDI-II points per 10 FIM points), lower income status (by 3.7 BDI-II points; P=0.007), and incomplete secondary education (by 3.8 BDI-II points; P 0.009). The highest BDI-II was observed in patients aged 45 to 50 years. There was no correlation between depressive symptoms and comorbidities (P=0.92), sex (P=0.25), ICU LOS (P=0.51), or caregiver variables (Caregiver Assistance Scale [P=0.28] and Center for Epidemiologic Studies Depression Scale [P=0.74]). Read more