Drug reaction with eosinophilia and systemic symptoms (DRESS) is a Severe Cutaneous Adverse Drug Reaction (SCAR), which can be life‐threatening. In the acute phase, the potentially culprit drugs must be immediately discontinued, and these medications remain contraindicated after recovery. However, most patients have taken several drugs before or at the beginning of their SCAR. No in vitro tests are available in daily practice to identify the responsible drug. In non‐severe drug reactions, skin tests and drug re‐challenges are considered the method of reference to establish or exclude hypersensitivity to drugs.
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