Oncology Round-Up: Bevacizumab and Gemcitabine with Cisplatin; and More

Bevacizumab and Gemcitabine with Cisplatin in Esophageal Cancer

Researchers performed a randomized clinical trial to examine the efficacy of bevacizumab and gemcitabine plus cisplatin in patients with esophageal cancer, with a focus on adverse reactions. In the report, published in BioMed Research International, the study’s authors stated that “the clinical efficiency of bevacizumab and gemcitabine combined with cisplatin in the treatment of esophageal cancer is remarkable.”

Abnormal Spindle Microtubule Assembly Gene Function in Cancer

Researchers, led by Tingting Deng, evaluated the impact of ASPM expression on tumor immunity and prognosis in different tumor samples and concluded that “the high expression of ASPM indicates poor prognosis as well as increased levels of immune cell infiltration in kidney renal clear cell carcinoma (KIRC) and liver hepatocellular carcinoma (LIHC).”

MICAL-L2 Expression in Colon Adenocarcinoma Prognosis

Researchers investigated the role of a protein in the molecules interacting with CasL (MICAL) family, MICAL-like protein 2 (MICAL-L2), in patients with colon adenocarcinoma (COAD). Using public databases, co-lead authors Yixing Yang and Fengwen Ye and colleagues investigated expression levels of MICAL-L2, and proposed that their data “suggested that MICAL-L2 is a promising biomarker for determining prognosis and correlated with immune infiltration levels in COAD.”

Creative Arts Therapy Improves Overall Quality of Life in Young Cancer Patients

Creative arts therapy (CAT) can improve overall quality of life for cancer patients, according to the study “Quality of Life Outcomes with Creative Arts Therapy in Children with Cancer” that was published in the Journal of Pediatric Oncology Nursing. Jennifer Raybin, PhD—a former dancer and dance instructor, as well as CU Cancer Center member—is a nurse practitioner who led the Palliative Care Program at Children’s Hospital in Colorado, and believes creative activities can help with patients’ mind-body connections by improving their moods and can even lessen symptoms like pain, nausea, and fatigue.