Hispanic Men Do Not Have Worse Outcomes than White Men Following Radical Prostatectomy

Hispanic men who undergo radical prostatectomy (RP) in an equal access setting do not appear to have worse outcomes than white men, according to a study published in Urology.

To conduct this study, researchers identified 3,789 white men (6% Hispanic) who underwent RP between 1988 and 2017 and categorized the population of interest as Hispanic or non-Hispanic. They used logistic regression to assess the correlation between ethnicity and prostate cancer adverse features. Cox models were used to test the association between ethnicity and biochemical recurrence (BCR), metastases, and castration-resistant prostate cancer (CRPC). All models were adjusted for age, prostate-specific antigen, clinical stage, biopsy grade group, surgery year, and surgical center.

According to the results, Hispanic men had higher prostate-specific antigen, but all other characteristics were similar between ethnicities, the researchers noted. A multivariable analysis showed no discernible difference between ethnicities in odds of extracapsular extension, seminal vesicle invasion, positive margins, positive lymph nodes, or high-grade disease. Overall, the study revealed that there was no significant correlation between Hispanic ethnicity and risk of BCR, metastases, or CRPC.

“In an equal access setting, we found no evidence Hispanic white men undergoing RP had worse outcomes than non-Hispanic white men,” the researchers concluded. “In fact, all hazard ratios were <1 and although they did not achieve statistical significance, suggest perhaps slightly better outcomes for Hispanic men.”

However, the researchers added, “Larger studies are needed to confirm findings.”