Comparing Mexican American vs White Prostate Cancer Active Surveillance Candidates

Mexican American men with favorable intermediate risk of prostate cancer (PCa) have higher rates of upgrading than white men, according to a study published in Urologic Oncology.

In this study, researchers used 2010 to 2015 information from the Surveillance, Epidemiology, and End Results database to identify 14,789 low risk and 10,834 favorable intermediate risk patients with PCa. Descriptive and logistic regression models were used for assessing data, and subgroup analysis was performed to test the association between Mexican-American versus Caucasian racial and/or ethnic groups and upgrading either to Gleason-Grade Group (GGG) II or to GGG III-V, in low risk or favorable intermediate risk patients with PCa, respectively.

The results showed that in low-risk patients with PCa, Mexican American men compared with white and/or ethnic men did not result in either upgrading or upstaging differences. However, the researchers noted, in favorable intermediate risk patients with PCa, the upgrading rate was higher in Mexican Americans than in Caucasians (31.4 vs. 25.5%; odds ratio [OR], 1.33; P=0.044), but no difference was recorded for upstaging. Furthermore, when comparing upgrading to GGG III-V, higher rates were recorded in Mexican American men relative to white men in favorable intermediate risk of PCa (20.4 vs. 15.4%; OR, 1.41; P=0.034).

The researchers wrote of the findings, “This information should be considered at treatment decision making.”