Long non-coding RNAs and their potential impact on diagnosis, prognosis, and therapy in prostate cancer: Racial, ethnic, and geographical considerations

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Expert Rev Mol Diagn. 2021 Oct 19. doi: 10.1080/14737159.2021.1996227. Online ahead of print.

ABSTRACT

Advances in high-throughput sequencing have greatly advanced our understanding of long non-coding RNA (lncRNAs) in a relatively short period of time. This has expanded our knowledge of cancer, particularly how lncRNAs drive many important cancer phenotypes via their regulation of gene expression.Areas covered:Men of African descent are disproportionately affected by PC in terms of incidence, morbidity, and mortality. LncRNAs could serve as biomarkers to differentiate low risk from high-risk disease. Additionally, they may represent therapeutic targets for advanced and castrate-resistant cancer. We review current research surrounding lncRNAs and their association with PC. We discuss how lncRNAs can provide new insights and diagnostic biomarkers in African American men. Finally, we review advances in computational approaches that predict the regulatory effects of lncRNAs in cancer.Expert opinion:PC diagnostic biomarkers which offer high specificity and sensitivity are urgently needed. PC specific lncRNAs are compelling as diagnostic biomarkers owing to their high tissue and tumor specificity and presence in bodily fluids Recent studies indicate that PCA3 clinical utility might be restricted to men of European descent. Further work is required to develop lncRNA biomarkers tailored for men of African descent.

PMID:34666586 | DOI:10.1080/14737159.2021.1996227