An Assessment of the CDC Breast and Prostate Cancer Data Quality and Patterns of Care Study

Researchers of a recent study sought to examine the association between radical prostatectomy (RP) and intensity-modulated radiation therapy (IMRT) treatment and survival among prostate cancer (PCa) patients. The results appeared in the Canadian Urological Association Journal.

To conduct this study, researchers procured records for localized PCa cases diagnosed in 2004 across seven state registries. The analysis comprised of 3,019 patients undergoing RP or IMRT (n=667). They assessed comorbidities using the the Adult Comorbidity Evaluation-27 (ACE-27). They also conducted a subgroup analysis of patients with high-risk PCa (RP, n=89; IMRT, n=95).

The results showed that IMRT was associated with a 41% increased risk of all-cause mortality (hazard ratio [HR]=1.41, 95% CI 1.13-1.76) but not PCa-specific mortality (HR=1.75, 95% CI 0.84-3.64), as compared to RP. The researchers observed, and noted that in patients with high-risk PCa, IMRT, as compared to RP, was not associated with statistically significant difference in all-cause (HR 1.53, 95% CI 0.97-2.42) or PCa-specific mortality (HR 1.92, 95% CI 0.69-5.36).

The investigators concluded that: “Despite a low mortality rate at 10 years and possible residual confounding, we found a significantly increased risk of all-cause mortality, but no PCa-specific mortality associated with IMRT as compared to RP in this population-based study.”