Analysis of the Significance of miR-141 and CD147 Expression in Bladder Cancer Cells and Its Relationship with Tumor Grade

Contrast Media Mol Imaging. 2022 May 17;2022:1335441. doi: 10.1155/2022/1335441. eCollection 2022.


The study analyzes the significance of miR-141 and extracellular matrix metalloproteinase-induced molecule (CD147) in bladder cancer cells and their correlation with tumor grade. A total of 87 bladder cancer patients for diagnosis and treatment from August 2020 to August 2021 are selected. All patients underwent pathological biopsy, and their cancer tissues and adjacent tissue cells are extracted. RT-PCR is used to complete the miR-141 relative expression level, and the immunohistochemical method is used to detect the expression of CD147 in patients. The miR-141 and CD147-positive rates are compared, and the relative expression levels of miR-141 and CD147-positive rates in cells of different tumor grades are compared. Spearman correlation coefficient is used to analyze the correlation of CD147 and bladder cancer. The prognosis of patients with different expression levels of miR-141 and CD147 is compared. Both miR-141 and CD147 are highly expressed in bladder cancer tissues, and their expression levels are significantly different from those of normal adjacent cells. In addition, the above two indicators are closely related to and related to the tumor grade of bladder cancer patients, and the high expression of miR-141 and CD147 brings the poor prognosis effect to bladder cancer patients.

PMID:35655727 | PMC:PMC9129955 | DOI:10.1155/2022/1335441