A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate

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Mol Cell Oncol. 2021 Sep 30;8(5):1974278. doi: 10.1080/23723556.2021.1974278. eCollection 2021.


The protein-lipid complex alpha1-oleate, derived from HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells), is identified as a molecular entity with significant therapeutic potential. Structural characterization of the complex and results of a successful placebo-controlled clinical trial are presented.

PMID:34859140 | PMC:PMC8632289 | DOI:10.1080/23723556.2021.1974278