Results from the TRIO study

When a knee is severely damaged by arthritis, and medications or walking supports are no longer helpful, some patients look into total knee arthroplasty (TKA). However, there might be patients that have a high risk of a poor outcome after TKAIn a study published in Rheumatology Advances in Practiceresearchers aim to develop and validate a simple clinical prediction model, based on easily collected preoperative information, to identify patients at high risk of pain and functional disability 6 months after TKA.

 The study was a multicenter cohort of patients from nine centers across the U.K.; patients enrolled in the study were undergoing a primary TKA for osteoarthritis (OA). The primary outcome measure for this analysis was the Oxford knee score (OKS), measured 6 months postoperatively by postal questionnaire,” the researchers said. Multivariable logistic regression was used to develop the model. Model performance (discrimination and calibration) and internal validity were assessed, and a simple clinical risk score was developed.” 

Out of 721 participants that presented data for the analysis, 14% had a poor outcome at 6 months. Key predictors were: 

  • Poor clinical status 
  • Widespread body pain 
  • High expectation of postoperative pain 
  • Lack of active coping 

“We have developed and validated a clinical prediction model that can be used to identify patients at high risk of a poor outcome after TKA,” the researchers concluded. “This clinical risk score may be an aid to shared decision-making between patient and clinician.” 


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SOURCE: Rheumatology Advances in Practice