Top 3 Cancer Related News from April 2019

3: A Bottle of Wine = 4-5 Cigarettes?

According to a study published in BMC Public Health, consuming a bottle of wine per week is equivalent to smoking five to 10 cigarettes per week in terms of increased lifetime risk of developing cancer.

Researchers estimated the increase in the absolute risk of developing cancer associated with moderate drinking and compared it with the increase in absolute risk of developing cancer secondary to smoking.

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2: Lymphoma Survivors Face Severe Fatigue

A study published in Cancer supports prior findings that long-term survivors of non-Hodgkin lymphoma (NHL) face severe fatigue.

The study involved two self-administered questionnaires: the 20-item Multidimensional Fatigue Inventory (MFI-20) and a Life Situation Questionnaire. In 2015, surveys were mailed to NHL survivors enrolled in 12 successive clinical studies conducted by the Lymphoma Study Association. Researchers obtained private addresses for 3,317 survivors, 1,671 (50%) of whom completed the questionnaires (906 men and 765 women). The median patient age was 64 years (range = 24-95 years).

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1: Study Shows CAR T-Cell Success in Solid Tumors

A phase I study presented at the American Association of Clinical Research Annual Meeting showed that chimeric antigen receptor (CAR) T-cells targeting mesothelin were active in patients with malignant pleural disease from mesothelioma and other solid tumors.

Researchers used a second-generation CD28-costimulated mesothelin CAR with the Icaspase-9 safety gene (IcasM28z). The study included 21 patients with biopsy-proven malignant pleural disease expressing mesothelin (19 with malignant pleural mesothelioma, 1 with lung cancer, and 1 with breast cancer). Patients received a single dose of IcasM28z CAR T-cells intrapleurally with or without cyclophosphamide preconditioning by either pleural catheter or an interventional radiology procedure.

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