Warning Sign: Postmenopausal Bleeding Occurs in 91% of Women With Endometrial Cancer

A study published in JAMA Internal Medicine found that postmenopausal bleeding (PMB) occurs in 91% of women with endometrial cancer; however, just 9% of those who experience PMB are actually diagnosed with endometrial cancer. 

The systematic review and meta-analysis assessed the literature using PubMed and Embase to identify English-language observational studies published between January 1, 1977, and January 31, 2017, reporting on the prevalence of PMB in women with endometrial cancer and the risk of endometrial cancer in women with PMB in unselected populations.  

The researchers selected 129 unique studies that included 34,432 unique patients with PMB and 6,358 with endometrial cancer. The pooled prevalence of PMB among women with endometrial cancer was 91%, regardless of tumor stage. The pooled risk of endometrial cancer among women with PMB was 9%, with estimates varying based on use of hormone therapy (range = 7-12%) and geographic region (range = 5-13%). 

“These findings provide a foundation for evaluating early detection strategies for endometrial cancer and can support risk-informed decision making in clinical management of PMB,” the researchers concluded.  

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Source: JAMA Internal Medicine