IL-17 Pathway in the Pathogenesis of Spondyloarthritis

Psoriatic arthritis, axial spondyloarthritis (SpA) and nonradiographic axial SpA, reactive arthritis, enteropathic arthritis and undifferentiated SpA are all inflammatory diseases that fall under “SpA.” Subtypes of the disease share clinical and immunological features, including joint inflammation; skin, gut and eye manifestations; and the absence of diagnostic autoantibodies; genetic factors are also shared by the diseases.  

The cause of SpA is still a subject of numerous research projects, but the research that has been done shows a clear role for the IL-17 pathway in the pathogenesis of SpA, according to a review study in Nature Reviews Rheumatology 

IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F are all a part of the IL-17 family, with IL-17A being the best studiedAccording to the review, of the six family members, IL-17A has the strongest homology with IL-17F. In this review, researchers discuss how IL-17A and IL-17F and their cellular sources might contribute to the immunopathology of SpA. 

Source: Nature Reviews Rheumatology