Patients who used copper intrauterine devices (Cu IUD) have a lower risk of developing cervical cancer compared to users of the levonorgestrel-releasing intrauterine system (LNG-IUS), according to a Columbia study recently published in Obstetrics & Gynecology.
Studies from the 1980s suggested reduced risk of cervical cancer among women who used an intrauterine contraceptive, though those studies did not differentiate between the varying types of IUDs. Also, much of the data from those studies was collected prior to the availability of most hormonal IUDs (LNG-IUS).
To conduct this study, the research team ran a retrospective cohort analysis of more than 10,000 patients who received IUDs. The diagnosis of high-grade cervical neoplasia was 0.7% in the Cu IUD cohort and 1.8% in the LNG-IUS cohort.
“Copper and hormonal IUDs may have different physiological effects on the female genitourinary system,” says Matthew Spotnitz, MD, MPH, a Postdoctoral Research Scientist within the Department of Biomedical Informatics and lead author of this study in a press release. “Consequently, the risk of cervical neoplasms may be different for copper and hormonal IUD users. Our findings may help patients and healthcare providers make informed decisions about whether the benefits of hormonal IUD use, compared to copper IUD use, are greater than the risks.”
Spotnitz noted that the research team hopes to lead a network study across other databases within the OHDSI network, which spans 19 countries, 133 unique databases converted to the OMOP CDM, and more than one billion patient records.
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“The proportions of women who use copper and hormonal IUDs may vary among institutions,” Spotnitz says. “Overall, IUD use has become more popular over the past 20 years. Copper IUD use has remained constant whereas hormonal IUD use has increased. The rising popularity of hormonal IUDs may be related to the fact that they decrease the pain and bleeding of menses.”
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