Hem/Onc Roundup: Germ Exposure Level Linked to Leukemia, Stress Associated With Cervical Cancer Death, and more

Here are the top stories covered by DocWire News this week in the Hematology & Oncology section. This week, a study found that exposure to germs early in life reduces the risk of leukemia, a novel drug improved survival for patients with stomach cancer, and more.

A study published in Nature Reviews Cancer found that a lack of exposure to germs early in life, followed by an infection, increases the risk for childhood leukemia. The study found that when a baby is exposed to infections during its first year, the immune system is strengthened. But when the child experiences later infections, without the initial exposure to germs, leukemia can be triggered in those with the genetic predisposition.

Topline results from the pivotal phase III INVICTUS trial showed that the novel drug ripretinib improved progression-free survival (primary endpoint) compared with placebo in patients with gastrointestinal stromal tumors, according to a press release from the drug’s manufacturer.

The chimeric antigen receptor T-cell therapy tisagenlecleucel showed measurable in vivo expansion in patients with relapsed/refractory diffuse large B-cell lymphoma who had no measurable disease after bridging therapy, according to a study published in Blood Advances.

A study published in Blood found that having a parent, sibling, or child with blood cancer increases a person’s likelihood of being diagnosed with the disease. The majority of hematological malignancies showed increased familial relative risks (FRRs) for the same tumor type, with the highest FRRs observed for mixed cellularity Hodgkin lymphoma, lymphoplasmacytic lymphoma, and mantle cell lymphoma.

Psychiatric disorders and stressful life events that occur around a cervical cancer diagnosis are associated with increased cancer-specific mortality, independent of tumor characteristics and treatment modality, according to a study published in Cancer Research.

In case you missed it, more hem/onc headlines are featured below:

Women with Sleep Apnea May Have Higher Risks for Cancer