Adverse Pregnancy Outcomes Reported for Women Diagnosed With CIN 3

Women with cervical intraepithelial neoplasia grade 3 (CIN 3) have adverse pregnancy outcomes, although the risks have attenuated over time, according to a study published online Feb. 8 in the Annals of Internal Medicine.

Wei He, Ph.D., from The Children’s Hospital in Hangzhou, China, and colleagues conducted a population- and sibling-matched cohort study to examine pregnancy outcomes among women diagnosed with CIN 3 in Sweden from 1973 to 2018. A total of 78,450 singletons born to women diagnosed with CIN 3 were compared to 784,500 matched singletons born to women in the general population. The sibling cohort included 23,199 singletons born to women diagnosed with CIN 3 and 28,135 singletons born to their sisters who did not have CIN 3.

The researchers found that women previously diagnosed with CIN 3 were more likely than the matched general population to have a preterm birth, especially extremely preterm birth (22 to 28 weeks: odds ratio, 3.00), or to have spontaneous preterm birth (odds ratio, 2.12); infection-related outcomes, including chorioamnionitis and infant sepsis (odds ratios, 3.23 and 1.72, respectively); or early neonatal death (odds ratio, 1.83). Results were largely similar for sibling comparison analyses. The risk differences for all outcomes were attenuated over time and disappeared for early neonatal death.

“These results suggest that women treated for CIN 3 should be recognized as ‘high-risk’ and managed accordingly to reduce the risk for adverse pregnancy outcomes,” the authors write.

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