Valentina O. Puntmann, MD, PhD, from the University Hospital Frankfurt in Germany, and colleagues examined the presence of myocardial injury in 100 patients recently recovered from COVID-19 illness (67 recovered at home; 33 required hospitalization). Cardiovascular magnetic resonance (CMR) imaging was obtained for all patients; the median interval between COVID-19 diagnosis and CMR imaging was 71 days.
The researchers found that among patients recently recovered from COVID-19, high-sensitivity troponin T was detectable in 71 patients and was significantly elevated in five patients at the time of CMR imaging. Patients recently recovered from COVID-19 had lower left ventricular ejection fraction, higher left ventricular volumes, higher left ventricle mass, and raised native T1 and T2 compared with a group of 50 healthy controls and 57 risk factor-matched patients. Abnormal CMR imaging findings occurred in 78 percent of patients recently recovered from COVID-19, including raised myocardial native T1 and T2 (73 and 60 patients, respectively), myocardial late gadolinium enhancement (32 patients), and pericardial enhancement (22 patients). There was a correlation noted for high-sensitivity troponin T with native T1 and T2 mapping. Native T1 and T2 were the measures with the best discriminatory ability to detect myocardial pathology related to COVID-19.
“The results of our study provide important insights into the prevalence of cardiovascular involvement in the early convalescent stage,” the authors write.
Several authors disclosed financial ties to the pharmaceutical industry.
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What happens to the heart with #COVID19?
1. By MRI (N=100), most patients had ongoing inflammation, some dysfunctionhttps://t.co/UR0iWGQVG1
2. At autopsy (N=36), virus present in myocytes in most patients, many at high copy Nhttps://t.co/YYAsonvTKi @dirkwestermann @JAMACardio pic.twitter.com/SEf7O0py7O
— Eric Topol (@EricTopol) July 27, 2020
In 100 unselected patients recently recovered from #COVID19, cardiac magnetic resonance imaging revealed cardiac involvement in 78% and ongoing myocardial inflammation in 60%, which was independent of preexisting conditions. Via @JAMACardio https://t.co/FX5cSH3nnt pic.twitter.com/9I9jhwUsqT
— Muin J. Khoury (@MuinJKhoury) July 27, 2020
This is important. For non-medical folx, this means that the heart is directly affected by #COVID19 in almost everyone who is infected. Here's a lay person summary from April (which doesn't include this new information) https://t.co/ezz6i7GPiC https://t.co/BtTKoyjsTD
— Mary L. Brandt, MD (@drmlb) July 27, 2020