Check out this week’s roundup for some interesting food-and-beverage-related updates, and a potential benefit from the administration of drugs used for opioid treatment.
Opioid Treatment, When Given, Improves Outcomes for Endocarditis
This retrospective cohort study included data on 768 individuals (51% male, mean age 39 years) from a large commercial health insurance database. The primary study outcomes of interest were opioid-related overdose and one-year all-cause rehospitalization. The authors calculated incidence rates for the outcomes and used Cox hazard models to predict time from discharge to each outcome as a function of MOUDs administration. “Endocarditis, once predominately found in older adults, is increasingly common among younger persons who inject drugs,” the authors wrote in their abstract. “Untreated opioid use disorder complicates endocarditis management. We aimed to determine if rates of overdose and rehospitalization differ between persons with opioid use disorder with endocarditis who are initiated on medications for opioid use disorder (MOUDs) within 30 days of hospital discharge and those who are not.”
This analysis, published in the Journal of the American Heart Association, looked at two major sources of sugar in U.S. diets: sugar-sweetened beverages and 100% fruit juices, as well as low-calorie sweetened beverages often used as replacements. According to their results, regular consumption of sugary beverages (more than one serving per day) was linked with a higher mean decrease in HDL-C (P for trend<0.0001) and increased triglyceride concentrations (P for trend=0.003) . The long-term regular consumption of sugar-sweetened beverages coincided with a higher incidence of high triglyceride levels compared with those who consumed low amounts of sugary drinks. They also reported that cumulative average intakes of low-calorie sweetened beverages were not linked with changes in non-HDL-C, LDL-C concentrations, or incident dyslipidemias.
“This study shows that we can accurately predict the likelihood of hospitalization for heart failure deterioration well before doctors and patients know that something is wrong,” lead author Josef Stehlik, MD, MPH, co-chief of the advanced heart failure program at University of Utah Health, said in a press release. “Being able to readily detect changes in the heart sufficiently early will allow physicians to initiate prompt interventions that could prevent rehospitalization and stave off worsening heart failure.” The study authors reported 35 unplanned nontrauma hospitalization events, with 24 worsening heart failure events. According to the study results, the platform was able to detect precursors of heart failure hospitalization exacerbation with 76% to 88% sensitivity and 85% specificity. The median reported time between an initial clinical alert and readmission was 6.5 days.
According to the study results, a higher consumption of fruits/vegetables (per 200 g/day higher intake, HR=0.87; 95% CI, 0.82 to 0.93; P-trend<0.001), dietary fiber (per 10 g/day, HR=0.77; 95% CI, 0.69 to 0.86, P-trend<0.001), milk (per 200 g/day, HR=0.95; 95% CI, 0.91 to 0.99, P-trend=0.02), yogurt (per 100 g/day, HR=0.91; 0.85 to 0.97, P-trend=0.004), and cheese (per 30 g/day, HR=0.88; 95% CI, 0.81 to 0.97, P-trend=0.008) were linked with reductions in ischemic stroke risk. Those at higher stroke risk tended to consume more red meat. “The most important finding is that higher consumption of both dietary fiber and fruit and vegetables was strongly associated with lower risks of ischemic stroke, which supports current European guidelines,” an author said in a press release. “The general public should be recommended to increase their fiber and fruit and vegetable consumption, if they are not already meeting these guidelines.”